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Targeted Allele Detail
Symbol: Xrcc5tm1Dbr
Name: X-ray repair complementing defective repair in Chinese hamster cells 5; targeted mutation 1, David B Roth
MGI ID: MGI:2179987
Synonyms: Ku80-, Ku86-, xrcc5-, xrcc5M1
Gene: Xrcc5  Location: Chr1:72307427-72394952 bp, + strand  Genetic Position: Chr1, 36.5 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:34834
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details6 kb of this gene encoding amino acids 229-313 were replaced with a PGK-puro cassette via homologous recombination resulting in a frameshift after residue 313 and deleting 69% of the protein product. Northern blot analysis and RT-PCR of embryonic fibroblasts from homozygous mutants did not detect gene transcript. (J:34834)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xrcc5 Mutation:  28 strains or lines available
Original:  J:34834 Zhu C, et al., Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 1996 Aug 9;86(3):379-89
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory