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Xrcc6tm1Fwa
Targeted Allele Detail
Nomenclature
Symbol: Xrcc6tm1Fwa
Name: X-ray repair complementing defective repair in Chinese hamster cells 6; targeted mutation 1, Frederick W Alt
MGI ID: MGI:2179954
Synonyms: Ku70-, Ku70DKO
Gene: Xrcc6  Location: Chr15:81987835-82040085 bp, + strand  Genetic Position: Chr15, 38.33 cM, cytoband E-F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44361
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details450 bp of this gene encompassing exon 4 and part of exon 5 were replaced with a neo cassette via homologous recombination resulting in a shift in the reading frame and predicted protein truncation after the first 64 residues. Homozygous mutant ES cells were identified by Southern blot analysis and Western blot analysis confirmed the absence of protein product. (J:41941, J:44361)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xrcc6 Mutation:  38 strains or lines available
References
Original:  J:44361 Gu Y, et al., Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 1997 Nov;7(5):653-65
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory