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Targeted Allele Detail
Symbol: Asic1tm1Wsh
Name: acid-sensing (proton-gated) ion channel 1; targeted mutation 1, Michael J Welsh
MGI ID: MGI:2179834
Synonyms: ASIC-, ASIC1-, ASIC1a-
Gene: Asic1  Location: Chr15:99670718-99701127 bp, + strand  Genetic Position: Chr15, 56.13 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:76361
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 of this gene was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of the first 121 amino acids, which includes the intracellular N terminus, the first transmembrane domain, and a portion of the extracellular domain. Immunoprecipitation and Western blot analysis failed to detect protein in extracts from brain and hippocampus of homozygous mutant animals. (J:76361)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asic1 Mutation:  25 strains or lines available
Original:  J:76361 Wemmie JA, et al., The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 2002 Apr 25;34(3):463-77
All:  34 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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