About   Help   FAQ
Scnn1btm1Ipt
Targeted Allele Detail
Nomenclature
Symbol: Scnn1btm1Ipt
Name: sodium channel, nonvoltage-gated 1 beta; targeted mutation 1, Edith Hummler
MGI ID: MGI:2179831
Synonyms: betaENaC m/m
Gene: Scnn1b  Location: Chr7:121865111-121918515 bp, + strand  Genetic Position: Chr7, 65.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53057
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA stop codon followed by a loxP-flanked neomycin resistance cassette was inserted at a position corresponding to residue arg566 in the human gene. Northern blot analysis on colon, kidney and lung RNA revealed that a low level (1-4%) of a truncated transcript was expressed from this allele. (J:53057)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1b Mutation:  9 strains or lines available
References
Original:  J:53057 Pradervand S, et al., Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1732-7
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/07/2015
MGI 5.21
The Jackson Laboratory