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Nrcamtm1Fgr
Targeted Allele Detail
Nomenclature
Symbol: Nrcamtm1Fgr
Name: neuronal cell adhesion molecule; targeted mutation 1, Fritz G Rathjen
MGI ID: MGI:2179756
Gene: Nrcam  Location: Chr12:44328885-44601846 bp, + strand  Genetic Position: Chr12, 20.71 cM
Nrcamtm1Fgr/Nrcamtm1Fgr mice develop cataracts and display reduced body weight and motor disabilities

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70385
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 4, which includes the start codon. Western blot analysis of homogenates of homozygous brains confirmed the absence of encoded protein. (J:70385)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrcam Mutation:  41 strains or lines available
References
Original:  J:70385 More MI, et al., Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation. J Cell Biol. 2001 Jul 9;154(1):187-96
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory