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Targeted Allele Detail
Symbol: Ank2tm1Bnt
Name: ankyrin 2, brain; targeted mutation 1, Vann Bennett
MGI ID: MGI:2179754
Synonyms: AnkyrinB -
Gene: Ank2  Location: Chr3:126921612-127499350 bp, - strand  Genetic Position: Chr3, 56.07 cM
Small body size in Ank2tm1Bnt/Ank2tm1Bnt mouse compared to wild type

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:52124
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene, an in-frame HA epitope and a stop codon were inserted into the exon encoding the spectrin binding domain. Northern blot analysis on RNA derived from homozygous brains demonstrated that no detectable transcript was expressed from this allele. Western blot analysis on homogenates of homozygous brain confirmed that no encoded protein was present. (J:52124)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ank2 Mutation:  17 strains or lines available
Phenotypic Similarity to Human Syndrome: Sinoatrial (SAN) disease (J:163867)
Original:  J:52124 Scotland P, et al., Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. J Cell Biol. 1998 Nov 30;143(5):1305-15
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory