About   Help   FAQ
Kcnab2tm1Kmc
Targeted Allele Detail
Nomenclature
Symbol: Kcnab2tm1Kmc
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2; targeted mutation 1, Ken McCormack
MGI ID: MGI:2179738
Synonyms: Kvbeta2-
Gene: Kcnab2  Location: Chr4:152390742-152477871 bp, - strand  Genetic Position: Chr4, 83.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75891
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo cassette was used to disrupt the beta sheet structural element of this gene via homologous recombination resulting in a structurally unstable protein product. Immunofluorescent staining and Western blot analysis of brain lysate from homozygous mutant animals confirmed the absence of protein product. (J:75891)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnab2 Mutation:  2 strains or lines available
References
Original:  J:75891 McCormack K, et al., Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem. 2002 Apr 12;277(15):13219-28
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/07/2015
MGI 5.21
The Jackson Laboratory