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Kcnab2tm1Kmc
Targeted Allele Detail
Nomenclature
Symbol: Kcnab2tm1Kmc
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2; targeted mutation 1, Ken McCormack
MGI ID: MGI:2179738
Synonyms: Kvbeta2-
Gene: Kcnab2  Location: Chr4:152390744-152477549 bp, - strand  Genetic Position: Chr4, 83.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75891
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo cassette was used to disrupt the beta sheet structural element of this gene via homologous recombination resulting in a structurally unstable protein product. Immunofluorescent staining and Western blot analysis of brain lysate from homozygous mutant animals confirmed the absence of protein product. (J:75891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnab2 Mutation:  18 strains or lines available
References
Original:  J:75891 McCormack K, et al., Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem. 2002 Apr 12;277(15):13219-28
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory