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Lamb3IAP
Spontaneous Allele Detail
Nomenclature
Symbol: Lamb3IAP
Name: laminin, beta 3; intracisternal-A particle insertion
MGI ID: MGI:2179716
Gene: Lamb3  Location: Chr1:192976661-193026186 bp, + strand  Genetic Position: Chr1, 97.71 cM, cytoband H2-H6
Control and Lamb3IAP/Lamb3IAP histological skin section.

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Transposon insertion
 
Mutation detailsAn intracisternal-A particle was found to be inserted into the gene at the 3' end of a 0.55 kb intron at the intron/exon junction. Northern blot analysis on embryonic RNA demonstrated that no detectable transcript was expressed from this allele. (J:42382)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamb3 Mutation:  39 strains or lines available
References
Original:  J:42382 Kuster JE, et al., IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa. Mamm Genome. 1997 Sep;8(9):673-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory