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Targeted Allele Detail
Symbol: Map3k1tm1Glj
Name: mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Gary L Johnson
MGI ID: MGI:2179711
Synonyms: MEKK1 -
Gene: Map3k1  Location: Chr13:111746428-111808993 bp, - strand  Genetic Position: Chr13, 63.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:62909
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene in the antisense orientation replaced 132 codons, including the ATG start site in exon 1. (J:62909)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Map3k1 Mutation:  33 strains or lines available
Original:  J:62909 Yujiri T, et al., MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7272-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory