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Prkcdtm1Kin
Targeted Allele Detail
Nomenclature
Symbol: Prkcdtm1Kin
Name: protein kinase C, delta; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:2179710
Synonyms: nPKDdelta-, PCK-delta-, PKCdelta-
Gene: Prkcd  Location: Chr14:30595358-30626210 bp, - strand  Genetic Position: Chr14, 18.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76135
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neomycin resistance gene via homologous recombination. Protein product was absent in brain of homozygous mutant animals as determined by Western blot analysis. (J:76135)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkcd Mutation:  9 strains or lines available
References
Original:  J:76135 Miyamoto A, et al., Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002 Apr 25;416(6883):865-9
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory