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Targeted Allele Detail
Symbol: Nfkb1tm1Brv
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:2179707
Synonyms: NF-kappaB KO, Nfkb1deltaCT, p105 -, p50
Gene: Nfkb1  Location: Chr3:135584655-135691547 bp, - strand  Genetic Position: Chr3, 62.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:46912
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the gene, disrupting the carboxy terminal domain of the encoded protein. Western blot analysis on lystates derived from thymus of homozygous mice confirmed that the p50 isoform of the protein was expressed, but the p105 precursor was not detectable. (J:46912)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb1 Mutation:  90 strains or lines available
Original:  J:46912 Ishikawa H, et al., Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50. J Exp Med. 1998 Apr 6;187(7):985-96
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory