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Targeted Allele Detail
Symbol: Nfkb2tm1Brv
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:2179689
Synonyms: p100-
Gene: Nfkb2  Location: Chr19:46304320-46312090 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Stomach abnormalities in Nfkb2tm1Brv/Nfkb2tm1Brv mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:43469
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe carboxy terminal domain of the protein was disrupted by insertion of a termination codon at position 451 and the replacement of the sequences encoding residues 451 to 690 with a neomycin resistance cassette. Immunoprecipitation analysis on lysates of stimulated thymocytes demonstrated that the larger precursor protein was not made, but a processed and truncated p52 protein was present. (J:43469)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:  38 strains or lines available
Original:  J:43469 Ishikawa H, et al., Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med. 1997 Oct 6;186(7):999-1014
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory