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Reltm1Grd
Targeted Allele Detail
Nomenclature
Symbol: Reltm1Grd
Name: reticuloendotheliosis oncogene; targeted mutation 1, Steve Gerondakis
MGI ID: MGI:2179622
Synonyms: c-rel-, cRel-
Gene: Rel  Location: Chr11:23741729-23770970 bp, - strand  Genetic Position: Chr11, 14.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28435
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a genomic fragment containing exons 4-9, which encode regions required for DNA binding, dimerization, nuclear transport and transcriptional trans-acrivation. (J:28435)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rel Mutation:  29 strains or lines available
References
Original:  J:28435 Kontgen F, et al., Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995 Aug 15;9(16):1965-77
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory