About   Help   FAQ
Targeted Allele Detail
Symbol: Ccr6tm1Lira
Name: chemokine (C-C motif) receptor 6; targeted mutation 1, Sergio A Lira
MGI ID: MGI:2179552
Synonyms: CCR6-, Ccr60, D6-
Gene: Ccr6  Location: Chr17:8236043-8257141 bp, + strand  Genetic Position: Chr17, 4.9 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:76461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced most of the coding region. Northern analysis of spleen did not detect mRNA in homozygous mutant mice. Binding studies did not detect ligand on membranes prepared from spleens of homozygous mutant mice. (J:76461)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr6 Mutation:  20 strains or lines available
ES cell line strain of origin is given in J:76461 as "129 SvE."
Original:  J:76461 Cook DN, et al., CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity. 2000 May;12(5):495-503
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory