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Cfc1tm1Mms
Targeted Allele Detail
Nomenclature
Symbol: Cfc1tm1Mms
Name: cripto, FRL-1, cryptic family 1; targeted mutation 1, Michael M Shen
MGI ID: MGI:2179530
Synonyms: Cryptic
Gene: Cfc1  Location: Chr1:34535648-34544313 bp, + strand  Genetic Position: Chr1, 13.34 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58104
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 3 and all of exons 4 and 5 were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant E7.5 embryos were identified by PCR analysis. (J:58104)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfc1 Mutation:  15 strains or lines available
References
Original:  J:58104 Yan YT, et al., Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 1999 Oct 1;13(19):2527-37
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory