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Traf2tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Traf2tm1Mak
Name: TNF receptor-associated factor 2; targeted mutation 1, Tak W Mak
MGI ID: MGI:2179513
Synonyms: TRAF2-
Gene: Traf2  Location: Chr2:25517982-25546940 bp, - strand  Genetic Position: Chr2, 17.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44360
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the two exons encoding the ring finger domain. Immunoprecipitation and western blot analysis on lysates derived from homozygous mice confirmed that no detecable protein was expressed. (J:44360)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Traf2 Mutation:  9 strains or lines available
References
Original:  J:44360 Yeh WC, et al., Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity. 1997 Nov;7(5):715-25
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory