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Targeted Allele Detail
Symbol: Gsntm1Djk
Name: gelsolin; targeted mutation 1, David J Kwiatkowski
MGI ID: MGI:2179509
Gene: Gsn  Location: Chr2:35256380-35307892 bp, + strand  Genetic Position: Chr2, 23.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:24346
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the first coding exon, 60 bp downstream of the initiation codon. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no transcript was produced from this allele. Activity assays and western blotting experiments confirmed that no functional protein was expressed. (J:24346)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gsn Mutation:  5 strains or lines available
Original:  J:24346 Witke W, et al., Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7;81(1):41-51
All:  19 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory