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Onecut1tm1Flem
Targeted Allele Detail
Nomenclature
Symbol: Onecut1tm1Flem
Name: one cut domain, family member 1; targeted mutation 1, Frederic P Lemaigre
MGI ID: MGI:2179340
Synonyms: Hnf6-
Gene: Onecut1  Location: Chr9:74861921-74891781 bp, + strand  Genetic Position: Chr9, 41.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62595
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe proximal promoter region and exon 1 were replaced with a neomycin cassette via homologous recombination. Absence of gene expression in pancreas of homozygous mutant animals was verified by RT-PCR. (J:62595)
Phenotypes
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Expression
In Mice Carrying this Mutation: 101 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Onecut1 Mutation:  2 strains or lines available
References
Original:  J:62595 Jacquemin P, et al., Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory