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Capns1tm1Pag
Targeted Allele Detail
Nomenclature
Symbol: Capns1tm1Pag
Name: calpain, small subunit 1; targeted mutation 1, Peter A Greer
MGI ID: MGI:2179226
Synonyms: Capn4-
Gene: Capns1  Location: Chr7:30186936-30198811 bp, - strand  Genetic Position: Chr7, 17.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74966
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsDisruption of the calpain small subunit gene was achieved by replacing the 3'-terminal half of exon 9 with a PGK-neo cassette. No calpain activity was detected in extracts from homozygous mutant ES cells. Although the large subunit genes were not altered and are transcribed, the resultant proteins are unstable in the absence of the small subunit. (J:74966)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Capns1 Mutation:  23 strains or lines available
References
Original:  J:74966 Arthur JS, et al., Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol. 2000 Jun;20(12):4474-81
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory