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Targeted Allele Detail
Symbol: Tbx1tm1Bld
Name: T-box 1; targeted mutation 1, Antonio Baldini
MGI ID: MGI:2179136
Synonyms: Tbx1-, Tbx1lacZ
Gene: Tbx1  Location: Chr16:18581704-18590671 bp, - strand  Genetic Position: Chr16, Syntenic
Cleft palate, absent thymus and ear and cardiovascular abnormalities in Tbx1tm1Bld/Tbx1tm1Bld mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67409
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-lacZ reporter gene followed by a loxP-flanked neomycin resistance cassette was inserted into exon 5, which encodes part of the T box domain resulting in a functionally null allele. (J:67409)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 140 assay results
In Structures Affected by this Mutation: 47 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  11 strains or lines available
Original:  J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
All:  56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory