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Col18a1tm1Hms
Targeted Allele Detail
Summary
Symbol: Col18a1tm1Hms
Name: collagen, type XVIII, alpha 1; targeted mutation 1, Harvard Medical School
MGI ID: MGI:2179134
Synonyms: Col18a1-
Gene: Col18a1  Location: Chr10:76888013-77002351 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband B5-C1
Alliance: Col18a1tm1Hms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75861
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK/neo cassette replaces exons 17-38 of the endogenous locus. The insertion disrupts all variant forms from the locus. (J:75861)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Col18a1tm1Hms
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Col18a1 Mutation:  138 strains or lines available
References
Original:  J:75861 Fukai N, et al., Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J. 2002 Apr 2;21(7):1535-44
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory