Col1a1^tm2Bst
Targeted Allele Detail

Summary

• Symbol: Col1a1^tm2Bst
• Name: collagen, type I, alpha 1; targeted mutation 2, Paul Bornstein
• MGI ID: MGI:2179130
• Synonyms: Exon 2deltaNeo
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^tm2Bst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73906
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: A gene targeting event resulted in the deletion of exon 2 and a silent single base mutation in exon 7. (J:73906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 167 strains or lines available

References

• Original: J:73906 Bornstein P, et al., The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. J Biol Chem. 2002 Jan 25;277(4):2605-13
• All: 2 reference(s)