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Adra2atm1Bkk
Targeted Allele Detail
Nomenclature
Symbol: Adra2atm1Bkk
Name: adrenergic receptor, alpha 2a; targeted mutation 1, Brian K Kobilka
MGI ID: MGI:2179108
Synonyms: alpha2A-, alpha2A-AR-, alpha2A-ARKO, alpha2A-KO
Gene: Adra2a  Location: Chr19:54033690-54037413 bp, + strand  Genetic Position: Chr19, 49.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76317
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette inserted into the gene by homologous recombination resulted in a premature stop codon within the third transmembrane domain. Confirmation of the targeting event was demonstrated through Southern analysis. (J:76317)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra2a Mutation:  19 strains or lines available
References
Original:  J:76317 Altman JD, et al., Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Mol Pharmacol. 1999 Jul;56(1):154-61
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory