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Serpind1tm1Toll
Targeted Allele Detail
Nomenclature
Symbol: Serpind1tm1Toll
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1; targeted mutation 1, Douglas M Tollefsen
MGI ID: MGI:2179102
Synonyms: HCII-
Gene: Serpind1  Location: Chr16:17331371-17343574 bp, + strand  Genetic Position: Chr16, 10.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74337
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 of this gene was replaced with a neomycin cassette via homologous recombination. Northern blot of liver from homozygous mutant animals detected a mutant transcript containing the neo sequence. Plasma from homozygous mutant animals did not contain protein product or exhibit enzyme activity. (J:74337)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Serpind1 Mutation:  0 strains or lines available
References
Original:  J:74337 He L, et al., Heparin cofactor II inhibits arterial thrombosis after endothelial injury. J Clin Invest. 2002 Jan;109(2):213-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory