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Tg(Camk2a-tTA)1Mmay
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-tTA)1Mmay
Name: transgene insertion 1, Mark Mayford
MGI ID: MGI:2179066
Synonyms: CamDAT, CaMKIIalpha-tTA, CaMKII-tTA, CAMK-rTA, line B, pCaMKII-tTA, Tgalpha-CaMkII-tTA, Tg(CaMKIItTA)Mmay
Transgene: Tg(Camk2a-tTA)1Mmay  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Transactivator)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Tg(Camk2a-tTA)1Mmay involves 5 genes/genome features (Vipr2, Wdr60, Esyt2 ...) View all
 
Mutation detailsThe transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. The transgene integrated into chromosome 12 causing a 508.12 Kb deletion and disrupting the following genes: Vipr2, Wdr60, Esyt2, Ncapg2, and Ptprn2. The deletion results in a functional knock-out of Vipr2, Wdr60, Esyt2, and Ncapg2 in homozygous mice. Founder line 1 has a copy number of greater than 20. (J:37107, J:253473)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Notes
This transgene is line B.

Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression.

References
Original:  J:37107 Mayford M, et al., Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 6;274(5293):1678-83
All:  230 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory