About   Help   FAQ
Transgene Detail
Symbol: Tg(Camk2a-tTA)1Mmay
Name: transgene insertion 1, Mark Mayford
MGI ID: MGI:2179066
Synonyms: CamDAT, CaMKIIalpha-tTA, CaMKII-tTA, CAMK-rTA, line B, pCaMKII-tTA, Tgalpha-CaMkII-tTA, Tg(CaMKIItTA)Mmay
Transgene: Tg(Camk2a-tTA)1Mmay  Location: Chr12:116064774-116572891 bp  Genetic Position: Chr12, Syntenic
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Null/knockout, Transactivator)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
Mutation detailsThe transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. The transgene integrated into chromosome 12 causing a 508.12 Kb deletion and disrupting the following genes: Vipr2, Wdr60, Esyt2, Ncapg2, and Ptprn2. The deletion results in a functional knock-out of Vipr2, Wdr60, Esyt2, and Ncapg2 in homozygous mice. Founder line 1 has a copy number of greater than 20. (J:37107)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
This transgene is line B.

Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression.

Original:  J:37107 Mayford M, et al., Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 6;274(5293):1678-83
All:  390 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.21
The Jackson Laboratory