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Targeted Allele Detail
Symbol: Skp2tm1Kin
Name: S-phase kinase-associated protein 2; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:2179051
Synonyms: Skp2-
Gene: Skp2  Location: Chr15:9111985-9155425 bp, - strand  Genetic Position: Chr15, 3.84 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:62130
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-4 of this gene were replaced with a PGK-neo-poly(A) cassette via homologous recombination, resulting in the loss of the translation initiation site and F-box domain. RT-PCR verified gene expression was absent in homozygous mutant animals and immunoprecipitation failed to detect full length or truncated protein product. (J:62130)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Skp2 Mutation:  13 strains or lines available
Original:  J:62130 Nakayama K, et al., Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000 May 2;19(9):2069-81
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory