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Cd44tm2Kmz
Targeted Allele Detail
Nomenclature
Symbol: Cd44tm2Kmz
Name: CD44 antigen; targeted mutation 2, Katalin Mikecz
MGI ID: MGI:2178950
Synonyms: CD44-
Gene: Cd44  Location: Chr2:102811141-102901665 bp, - strand  Genetic Position: Chr2, 54.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74268
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced most of exons 4 and 5 of this gene (encoding part of the hyaluronan binding domain and IM7 mAB recognition site) via homologous recombination. PCR and Southern Blot confirmed the integration of the neo gene in homozygous mutant animals. Synovial fibroblasts from homozygous mutant animals did not express mRNA as determined by Northern blot, and Western blot using IM7 mAB as a probe yielded negative results. (J:74268)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  32 strains or lines available
References
Original:  J:74268 Stoop R, et al., Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice. Arthritis Rheum. 2001 Dec;44(12):2922-31
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory