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Pik3ap1tm1Kuro
Targeted Allele Detail
Nomenclature
Symbol: Pik3ap1tm1Kuro
Name: phosphoinositide-3-kinase adaptor protein 1; targeted mutation 1, Tomohiro Kurosaki
MGI ID: MGI:2178861
Synonyms: BCAP-
Gene: Pik3ap1  Location: Chr19:41272541-41385102 bp, - strand  Genetic Position: Chr19, 34.61 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75075
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exon 8 of this gene containing 3 sequences encoding YxxM motifs. Northern blot did not detect gene transcripts in homozygous mutant animals. Western blot of splenic B cells from homozygous mutant animals failed to detect protein product. (J:75075)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ap1 Mutation:  35 strains or lines available
References
Original:  J:75075 Yamazaki T, et al., Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 2002 Mar 4;195(5):535-45
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory