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Wipf1tm1Geha
Targeted Allele Detail
Nomenclature
Symbol: Wipf1tm1Geha
Name: WAS/WASL interacting protein family, member 1; targeted mutation 1, Raif S Geha
MGI ID: MGI:2178802
Synonyms: WIP-
Gene: Wipf1  Location: Chr2:73429610-73529734 bp, - strand  Genetic Position: Chr2, 43.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74719
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 5 of this gene were replaced with a neo resistance gene via homologous recombination. Southern blot confirmed successful targeting of the construct in TC-1 ES cells. Western blot of thymocyte, lymph node, and splenocyte lysates confirmed the absence of protein product in homozygous mutant animals. (J:74719)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wipf1 Mutation:  14 strains or lines available
References
Original:  J:74719 Anton IM, et al., WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation. Immunity. 2002 Feb;16(2):193-204
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory