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Otx2tm4.1Sia
Targeted Allele Detail
Nomenclature
Symbol: Otx2tm4.1Sia
Name: orthodenticle homeobox 2; targeted mutation 4.1, Shinichi Aizawa
MGI ID: MGI:2178753
Synonyms: Otx2flox, Otx2/flox
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74631
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThis allele is a derivative of Otx2tm4Sia in which the neomycin resistance cassette was removed by crossing mice carrying the Otx2tm4Sia allele to mice expressing Flp recombinase in the germline. The final allele carries a single frt site in place of the frt-flanked neomycin cassette. (J:74631)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  45 strains or lines available
References
Original:  J:74631 Tian E, et al., Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory