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Slc6a4tm1Kpl
Targeted Allele Detail
Nomenclature
Symbol: Slc6a4tm1Kpl
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Klaus-Peter Lesch
MGI ID: MGI:2178613
Synonyms: 5-HTT-, 5-HTT KO, SERT -
Gene: Slc6a4  Location: Chr11:76998603-77032340 bp, + strand  Genetic Position: Chr11, 46.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76020
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a DNA segment containing exon 2. Binding assays on brain sections of adult homozygous mice confirmed that no functional protein was expressed from this allele. (J:76020)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Slc6a4 Mutation:  27 strains or lines available
References
Original:  J:76020 Bengel D, et al., Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol. 1998 Apr;53(4):649-55
All:  114 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory