Clec3b^tm1Umw
Targeted Allele Detail

Summary

• Symbol: Clec3b^tm1Umw
• Name: C-type lectin domain family 3, member b; targeted mutation 1, Ulla M Wewer
• MGI ID: MGI:2178555
• Synonyms: Tet -, Tna^tm1Umw
• Gene: Clec3b Location: Chr9:122980011-122986497 bp, + strand Genetic Position: Chr9, 73.91 cM, cytoband F1-F3
• Alliance: Clec3b^tm1Umw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72638
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The transcription start site and exon 1 (which contains the translation start site) were replaced by a neo cassette. RT-PCR and Northern blot analyses demonstrated absence of transcript from several tissues in homozygous mutant mice. Western blotting verified absence of protein from serum in mutant mice. (J:72638)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec3b Mutation: 13 strains or lines available

References

• Original: J:72638 Iba K, et al., Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity. Mol Cell Biol. 2001 Nov;21(22):7817-25
• All: 2 reference(s)