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Crhr1tm1Klee
Targeted Allele Detail
Nomenclature
Symbol: Crhr1tm1Klee
Name: corticotropin releasing hormone receptor 1; targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2178544
Synonyms: CRF1-, CRF-R1-, CRFR1 -
Gene: Crhr1  Location: Chr11:104132855-104175523 bp, + strand  Genetic Position: Chr11, 67.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48280
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 5-8, which encode part of the first transmembrane domain through the fourth transmembrane domain. (J:48280)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crhr1 Mutation:  8 strains or lines available
References
Original:  J:48280 Smith GW, et al., Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 1998 Jun;20(6):1093-102
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory