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Targeted Allele Detail
Symbol: Agtr2tm1Tin
Name: angiotensin II receptor, type 2; targeted mutation 1, Tadashi Inagami
MGI ID: MGI:2178475
Synonyms: AT2-, AT2 KO, AT2-KO, AT2R-, AT2tm1ti
Gene: Agtr2  Location: ChrX:21484624-21488833 bp, + strand  Genetic Position: ChrX, 16.71 cM
Enhanced bone mass in Agtr2tm1Tin/Y mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:29457
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a fragment of exon 3 containing most of the coding region of the gene. Northern blot analysis on RNA derived from E17 hemizygous male embryos or adult hemizygous male brain demonstrated that no transcript was expressed from this allele. (J:29457)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 31 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr2 Mutation:  5 strains or lines available
Original:  J:29457 Ichiki T, et al., Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995 Oct 26;377(6551):748-50
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory