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Brca1tm1Rfo
Targeted Allele Detail
Nomenclature
Symbol: Brca1tm1Rfo
Name: breast cancer 1; targeted mutation 1, Ricardo Fodde
MGI ID: MGI:2178447
Synonyms: Brca1(1700T)
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69602
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 20. RT-PCR analysis demonstrated that a mutant transcript was produced from this allele at normal expression levels. A truncated protein lacking the last BCRT repeat is predicted to be expressed from this allele. (J:69602)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  43 strains or lines available
References
Original:  J:69602 Hohenstein P, et al., A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory