Tg(Bmi1)52Mvl
Transgene Detail

Summary

• Symbol: Tg(Bmi1)52Mvl
• Name: transgene insertion 52, Maarten van Lohuizen
• MGI ID: MGI:2178139
• Synonyms: Emu-bmi-52
• Transgene: Tg(Bmi1)52Mvl Location: unknown
• Alliance: Tg(Bmi1)52Mvl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Bmi1)52Mvl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmi1 (MGI:88174)

• Mutation details: Insertion of a transgene consisting of a Bmi1 gene linked to a Pim1 promoter, the immunoglobulin enhancer, and a Moloney murine leukemia virus LTR causes overexpression of BMI1 in thymus, bone marrow, and spleen. This promoter and enhancer module gives high levels of transgene expression in lymphoid cells and is active early in development. (J:24505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:24505 Alkema MJ, et al., Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature. 1995 Apr 20;374(6524):724-7
• All: 4 reference(s)