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Targeted Allele Detail
Symbol: Hiratm1Pjs
Name: histone cell cycle regulator; targeted mutation 1, Peter J Scambler
MGI ID: MGI:2178130
Synonyms: Hiraneo
Gene: Hira  Location: Chr16:18877037-18970309 bp, + strand  Genetic Position: Chr16, 11.69 cM, cytoband A-B1
Germline Transmission:  Earliest citation of germline transmission: J:75491
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll of the coding sequence of exon 8 after amino acid position 183 was replaced with a neo/leu2 cassette. RT-PCR and western blotting experiments demonstrated an absence of encoded transcripts and protein, respectively. (J:75491)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hira Mutation:  25 strains or lines available
Original:  J:75491 Roberts C, et al., Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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