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Serpinc1tm1Sai
Targeted Allele Detail
Nomenclature
Symbol: Serpinc1tm1Sai
Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; targeted mutation 1, Hidehiko Saito
MGI ID: MGI:2178128
Synonyms: AT-, ATIII-
Gene: Serpinc1  Location: Chr1:160978585-161005863 bp, + strand  Genetic Position: Chr1, 69.75 cM
Subcutaneous hemorrhage in Serpinc1tm1Sai/Serpinc1tm1Sai mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65092
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2 and flanking intronic sequences. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and western blot analysis on liver lysates confirmed that no protein was expressed from this allele. (J:65092)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinc1 Mutation:  3 strains or lines available
References
Original:  J:65092 Ishiguro K, et al., Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest. 2000 Oct;106(7):873-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory