Serpinc1tm1Sai
Targeted Allele Detail
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Symbol: |
Serpinc1tm1Sai |
Name: |
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; targeted mutation 1, Hidehiko Saito |
MGI ID: |
MGI:2178128 |
Synonyms: |
AT-, ATIII- |
Gene: |
Serpinc1 Location: Chr1:160806153-160830113 bp, + strand Genetic Position: Chr1, 69.75 cM
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Alliance: |
Serpinc1tm1Sai page
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Subcutaneous hemorrhage in Serpinc1tm1Sai/Serpinc1tm1Sai mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:65092
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced exon 2 and flanking intronic sequences. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and western blot analysis on liver lysates confirmed that no protein was expressed from this allele.
(J:65092)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Serpinc1 Mutation: |
27 strains or lines available
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Original: |
J:65092 Ishiguro K, et al., Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest. 2000 Oct;106(7):873-8 |
All: |
4 reference(s) |
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