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Tcf3tm1Wein
Targeted Allele Detail
Nomenclature
Symbol: Tcf3tm1Wein
Name: transcription factor 3; targeted mutation 1, Harold Weintraub
MGI ID: MGI:2178112
Synonyms: E2A-, E2AdeltabHLH
Gene: Tcf3  Location: Chr10:80409514-80433647 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22134
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced two adjacent exons that encode alternative basic-helix-loop-helix transcription factors E12 and E47. (J:22134)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  25 strains or lines available
References
Original:  J:22134 Zhuang Y, et al., The helix-loop-helix gene E2A is required for B cell formation. Cell. 1994 Dec 2;79(5):875-84
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory