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Targeted Allele Detail
Symbol: Rims1tm1Sud
Name: regulating synaptic membrane exocytosis 1; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:2178099
Synonyms: RIM1alpha-, Rim1alphamt
Gene: Rims1  Location: Chr1:22288422-22805724 bp, - strand  Genetic Position: Chr1, 8.54 cM, cytoband A5
Germline Transmission:  Earliest citation of germline transmission: J:73900
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the first coding exon, which encodes the translation initiation site and 55 conserved N-terminal residues. Immunoblot analysis using antibody to the N-terminal zinc finger domain did not detect protein. (J:73900)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rims1 Mutation:  58 strains or lines available
Original:  J:73900 Schoch S, et al., RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature. 2002 Jan 17;415(6869):321-6
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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