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Grin1tm2Phs
Targeted Allele Detail
Summary
Symbol: Grin1tm2Phs
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2, Peter H Seeburg
MGI ID: MGI:2178083
Synonyms: NR1Rneo
Gene: Grin1  Location: Chr2:25181193-25209199 bp, - strand  Genetic Position: Chr2, 17.14 cM
Alliance: Grin1tm2Phs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75497
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsPoint mutations were introduced that altered codon 598 in exon 15 from one encoding asparagine to one encoding arginine (N598R). Expression is silenced by the presence in intron 18 of a loxP-flanked neomycin resistance cassette, whose removal by Cre recombinase will activate the mutant allele. (J:75497)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:  64 strains or lines available
References
Original:  J:75497 Single FN, et al., Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). J Neurosci. 2000 Apr 1;20(7):2558-66
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory