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Targeted Allele Detail
Symbol: Adarb1tm1Phs
Name: adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg
MGI ID: MGI:2178079
Synonyms: ADAR2 -
Gene: Adarb1  Location: Chr10:77290726-77418270 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:63273
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance gene replaced most of exon 4, which encodes domains essential for protein function. RNase protection assays demonstrated that a mutant transcript was produced from this allele at low levels that may express a functionally inactive protein with intact RNA binding domains. (J:63273)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adarb1 Mutation:  7 strains or lines available
Original:  J:63273 Higuchi M, et al., Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature. 2000 Jul 6;406(6791):78-81
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory