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Targeted Allele Detail
Symbol: F3tm1Dwr
Name: coagulation factor III; targeted mutation 1, Mieke Dewerchin
MGI ID: MGI:2178047
Synonyms: TFneo
Gene: F3  Location: Chr3:121723537-121735048 bp, + strand  Genetic Position: Chr3, 52.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:71271
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 6, encoding the last 18 amino acids, was deleted. In addition, a loxP-flanked neomycin resistance cassette was inserted into exon 5. Northen blot analysis confirmed the expression of a fusion transcript with the 3'UTR and neo cassette. (J:71271)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F3 Mutation:  3 strains or lines available
Original:  J:71271 Melis E, et al., Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem Biophys Res Commun. 2001 Aug 24;286(3):580-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory