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Targeted Allele Detail
Symbol: F2tm1Jes
Name: coagulation factor II; targeted mutation 1, J Evan Sadler
MGI ID: MGI:2177949
Synonyms: Cf2-
Gene: F2  Location: Chr2:91625329-91636407 bp, - strand  Genetic Position: Chr2, 50.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:48274
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic DNA fragment that contains exons 7-11, which encode one of the kringle domains, the activation cleavage site and part of the active site. Western blot analysis on liver extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:48274)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F2 Mutation:  31 strains or lines available
Original:  J:48274 Xue J, et al., Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7603-7
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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