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Targeted Allele Detail
Symbol: F2tm1Sjd
Name: coagulation factor II; targeted mutation 1, Sandra JF Degen
MGI ID: MGI:2177948
Synonyms: FII-
Gene: F2  Location: Chr2:91625329-91636407 bp, - strand  Genetic Position: Chr2, 50.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:48273
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn HPRT minigene replaced a genomic fragment containing exons 1 and 2, which encode the signal peptide and pro-peptide. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on liver extracts derived from plasma of homozygous mice confirmed that no protein was expressed from this allele. (J:48273)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F2 Mutation:  31 strains or lines available
Original:  J:48273 Sun WY, et al., Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7597-602
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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