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Nyxnob
Spontaneous Allele Detail
Summary
Symbol: Nyxnob
Name: nyctalopin; no b wave
MGI ID: MGI:2177945
Synonyms: nob
Gene: Nyx  Location: ChrX:13332349-13355552 bp, + strand  Genetic Position: ChrX, 8.37 cM
Alliance: Nyxnob page
Mutation
origin
Strain of Origin:  BALB/cGr-nr
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation in the nob mouse was identified as an 85 bp deletion in exon 3 of the gene. The deletion results in a frame shift that adds 170 unique amino acids to 188 amino acids from the amino terminus of the protein. This results in the loss of 288 amino acids fro the carboxyl terminus of the protein including seven leucine rich repeats. (J:81028)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nyx Mutation:  3 strains or lines available
Notes
Arose spontaneously on BALB/cGr-nr/nr (nervous) and then transferred to BALB/cByJ inbred strain (J:50824).
References
Original:  J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory