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Eif4ebp1tm1Nso
Targeted Allele Detail
Nomenclature
Symbol: Eif4ebp1tm1Nso
Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 1, Nahum Sonenberg
MGI ID: MGI:2177923
Synonyms: 4E-BP1 KO, Eif4ebp1-
Gene: Eif4ebp1  Location: Chr8:27260327-27275656 bp, + strand  Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72217
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe splice acceptor site and the first 57 nucleotides of exon 2 were replaced with the neomycin-resistance gene. The disrupted portion of exon 2 encodes amino acids 47 to 66, which encompasses the binding site for EIF4E. (J:72217)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Eif4ebp1 Mutation:  17 strains or lines available
References
Original:  J:72217 Tsukiyama-Kohara K, et al., Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med. 2001 Oct;7(10):1128-32
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory