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Targeted Allele Detail
Symbol: Mapk14tm1Mms
Name: mitogen-activated protein kinase 14; targeted mutation 1, Michael M Shen
MGI ID: MGI:2177832
Synonyms: p38alpha-
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Morphology and histology of wild type and Mapk14tm1Mms/Mapk14tm1Mms mouse embryos and placentas

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:73417
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance gene replaced part of exon 3 and part of intron 3. (J:73417)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
ES cell line = AB2.1 (129S7/SvEvBrd-Hprtb-m2) or W9.5 (129S1/Sv-p+ Tyr+ Kitl+).

Mutant mice were analyzed in four different strain backgrounds (129S/SvEv, C57BL/6, BALB/c, and outbred Black Swiss), with similar phenotypes in each case.

Original:  J:73417 Mudgett JS, et al., Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10454-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory