Mapk14^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Mms
• Name: mitogen-activated protein kinase 14; targeted mutation 1, Michael M Shen
• MGI ID: MGI:2177832
• Synonyms: p38alpha-
• Gene: Mapk14 Location: Chr17:28910303-28967380 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Mms page

Morphology and histology of wild type and Mapk14^tm1Mms/Mapk14^tm1Mms mouse embryos and placentas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73417
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance gene replaced part of exon 3 and part of intron 3. (J:73417)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 41 strains or lines available

Notes

ES cell line = AB2.1 (129S7/SvEvBrd-Hprt^b-m2) or W9.5 (129S1/Sv-p⁺ Tyr⁺ Kitl⁺).

Mutant mice were analyzed in four different strain backgrounds (129S/SvEv, C57BL/6, BALB/c, and outbred Black Swiss), with similar phenotypes in each case.

References

• Original: J:73417 Mudgett JS, et al., Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10454-9
• All: 3 reference(s)