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Mapk14tm1Mka
Targeted Allele Detail
Nomenclature
Symbol: Mapk14tm1Mka
Name: mitogen-activated protein kinase 14; targeted mutation 1, Michael Karin
MGI ID: MGI:2177830
Synonyms: p38alpha -
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63425
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the genomic sequence at a position corresponding to codon 97. Western blot and immunoprecipitation experiments confirmed that no detectable protein was expressed from this allele. (J:63425)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
References
Original:  J:63425 Tamura K, et al., Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory